Diablo 4 is packed to the brim with hell spawn, demons to slay, and endless waves of undead armies to burn through. Outside the never-ending minions that inhabit Sanctuary, the game also features loads of bosses to beat down too. While many of those bosses can be found through random encounters, World Boss sightings, and side missions, some of the main Big Baddies are fought through the main missions of Diablo 4.